I do not know about you, but I would not delete files out of the root, since you might break the dependencies and get problems with that.
Since you system is not generating errors with those files, and you do not know what app on your system is using it I would just leave them in peace.
OSXFUSE is a file management utility for Macs. Essentially it enables Macs to work better with the file systems of third-party applications.
For example SugarSync needs it, so do others.
If your Mac doesn't already have OSXFUSE, SugarSync will install the latest version along with the actual SugarSync application. This happens automatically. There is nothing you need to do.
This does not mean you have the sugarsync but just and example.
If you must then:
Here is some reading material.
Scan for Osxfuse app on your system to see where it is located.
Open console and type osxfuse in search, it will show you who called it in the lines before.
It is up to you if you want to just remove the osxfuse and find out which app is now generating errors.
There is also a script here, but I have NOT tested it